| SPEAKER |
| Prof Anthony Mathur |
| Consultant Cardiologist and Senior Lecturer in Cardiology |
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Barts and the London NHS Trust
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MEETING
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October 2009 |
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| BIOGRAPHY |
Anthony Mathur leads a collaborative group with Prof. John Martin (UCL) seeking to address the role of stem cells in the treatment of cardiovascular disease. This partnership has lead to the establishment of the largest series of clinical trials translating the interesting results produced by basic experimentation into relevant therapeutic approaches in man. The clinical work is also underpinned by a collaboration with Prof Suzuki (WHRI) to understand the basic mechanisms that are involved in stem cell repair of the heart.
Anthony Mathur?s other research interest is in advanced cardiac imaging and in particular its use to examine mechanistic aspects of translational research. He has assembled a state of the art collection of advanced imaging hardware (cardiac MR, PET/CT, cardiac CT, nuclear perfusion and advanced echo) that is strategically run through a joint imaging board that he chairs.
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| TALK |
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The REGENERATE clinical trials of Cell Therapy in Cardiac Disease
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| DESCRIPTION |
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Use of autologous bone marrow derived progenitor cells as a therapeutic to promote cardiac repair provides the first step in the development of cellular therapies as a strategy to treat disease. The REGENERATE series of randomised control clinical trials are designed to address whether the cardiac repair demonstrated by the use of bone marrow derived stem cells in pre-clinical research can translate to similar benefits in man. Funding from the UK Stem Cell Foundation and the Heart Cells Foundation has enabled the design and implementation of the three REGENERATE clinical trials which are the first of their kind in the UK and will be described in this lecture.
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