Jobs
Position available for Reader in Tissue Repair and Wound Healing/Director of Research, Blond McIndoe Research Foundation and University of Brighton
An opportunity has arisen to create a joint appointment between the School of Pharmacy and Biomolecular Sciences at the University of Brighton and the Blond McIndoe Research Foundation, East Grinstead.
This joint appointment, between the School of Pharmacy and Biomolecular Sciences and Blond McIndoe Research Foundation, will require a dynamic scientist with inspirational leadership qualities and a proven track record of international excellence in burns research and/or tissue engineering/biomaterials. The candidate will be expected to demonstrate an outstanding record of attracting research funding through charitable, industrial and other grant awarding bodies together with an exceptional, current publication history in prestigious scientific journals. They will have led their own research group or operated as an independent scientist within a larger group for a number of years and be able to lead and motivate a team. As Director of Research, they will be responsible for the strategic development and leadership of the research portfolio at the Blond McIndoe Research Foundation. This will involve building on the excellent collaborative programmes with research teams within local universities and NHS Trusts.
The appointment is based predominantly at the Blond McIndoe Research Foundation with a minimum of 0.5 day per week at the University of Brighton and is fixed-term for three years in the first instance. The salary range is from £46,846 to £54,283 per annum.
For more information about the post, please email Jacquie Pinney at the Blond McIndoe Research Foundation or Adrian J. Bone at the School of Pharmacy & Biomolecular Sciences, or call +44 (0)1273 642 849 or click here (REF: SP3084).
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Research Associate/Engineer position available at the Dept. Biochemical Engineering, UCL
The Advanced Centre for Biochemical Engineering at UCL has successfully established ultra scale-down (USD) technologies for the study of the recovery of human cells for therapy, and a new fixed term post covering maternity leave for one year is available shortly.
Particular duties will include responsibility for all aspects of the growth of human cell lines for the study, along with analytical characterization of cells, especially cell membrane integrity and concentration. This would involve a set-up with Stabilitech and implementation of frozen and liquid storage trials. Use of USD mimics of bioprocessing (especially capillary shear and centrifugation) to characterize the cell response to various storage regimes for different formulisation strategies would be involved. Reports will be based on a 3-monthly basis against a project plan to the Project Lead (S Ward at Stabilitech), Project Manager (V Adams at Stabilitech) and to the Technology Strategy Board. Monitoring will be performed of the project finances and reported back to UCL PI (Prof. Mike Hoare) on budget spend against planned spend.
The successful candidate will hold a PhD in relevant subject areas and will have already an established track record to work at a doctoral and preferably at postdoctoral level in areas including cell growth (mammalian cell culture is suitable, as it provides some of the skills needed for human cell culture), cell analysis, and characterization and ultra scale-down technologies. The successful candidate will demonstrate evidence of good research management skills, for example project planning, work to a project plan detailing tasks, deliverables and milestones and an awareness of the need for risk analysis and risk mitigation. Good publication track record and presentation skills are considered to be key skills for recruitment to this position.
This is a full time, 1-year Grade 7 position, with a salary range of £32,055-£38,744.
For further information, please click here and enter the reference number 1231691, or email Dr Stephen Ward.
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Post-doctoral research assistant position available at NHS Blood and Transplant Tissue Services, Liverpool, UK focused on the production of soluble extracellular matrices
This post is funded by NHS Blood and Transplant (NHSBT) and involves a collaboration between NHSBT Tissue Services, NHSBT Stem Cell Immunotherapies and the University of Leeds. NHSBT Tissue Services is the largest tissue bank in the UK, whose main function is to retrieve tissue from donors, process and store the tissue, and then issue the tissue to UK surgeons for tissue grafting procedures. The post will be based in the Tissue Development Laboratory in Liverpool; this is a purpose built laboratory whose role is to improve existing tissue allografts and develop novel therapies.
The use of cellular and tissue therapies to repair diseased or damaged tissue is an emerging field. The success of many of these therapies is reliant on the delivery and retention of the graft material at the site of implantation. This study will investigate methodologies for processing solid tissue allografts into injectable fluids that retain some of the ultrastructure of the original extracellular matrix (ECM) and which polymerise into a solid gel following administration. This study will investigate the potential of these ECM preparations to act as stand-alone grafts, inducing new tissue formation or the potential for them to act as carrier vehicles for bioactive molecules and cells, and thereby actively induce the formation of new tissue.
The successful applicant will be part of a multidisciplinary group consisting of tissue bankers, cell biologists, stem cell biologists and immunologists. He/she will initially be responsible for the development of a bone-derived soluble ECM that can be used both as a tissue graft and as a combined graft/carrier to deliver powdered demineralised bone matrix (DBM) in a viscous fluid/malleable paste or injectable format. The successful applicant will develop similar soluble ECMs from tendon, dermis and amnion, and will then develop in vitro assays for investigating the differentiative fate of mesenchymal stem cells added to the soluble ECMs. The post will involve liaising closely with the University of Leeds to evaluate the in vivo potential of the DBM soluble ECM.
This is a 3-year position, with a salary range of £30,460–£40,157 (probable maximum £35,184). Full details of the position and information on how to apply are available here, using the reference number 918-PP1630A.
For an informal discussion about this role please contact Dr. Paul Rooney either by telephone on: (0)151 268 7108 or by email to paul.rooney@nhsbt.nhs.uk.
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Research Associate in Tissue repair and regeneration at the Department of Dental Biomaterials Science, Biomaterials, Biomimetics and Biophotonics Research Group, Dental Institute, King’s College London
A new Research Associate position is available at the Department of Dental Biomaterials Science within the Biomaterials, Biomimetics and Biophotonics Research Group at the Dental Institute, King’s College London. The RA will provide support in the research and development of tissue engineered scaffolds for bone tissue engineering. Specifically, the aim will be to develop specialized nanocomposite scaffolds for tissue engineering, and regenerating cartilage and bone with the Principal Investigators of the appropriate project. Scaffold development will be based on nanotechnology procedures using a range of advanced processing techniques (e.g., electrospinning) in order to fabricate a gradient layer scaffold, which will require extensive characterisation. Biological optimization of the scaffolds will involve extensive biological testing and eventually the scaffold will be developed as a cell-seeded construct using a bioreactor.
They are seeking a highly-motivated, enthusiastic, and skilled post-doctoral Research Associate with experience in cell, molecular biology and material science. Preference will be given to candidates with experience in developing cell-seeded systems and characterising cell-material interactions with a demonstrable research output. In particular, osteogenic differentiation of adult stem cells, cell-seeded systems, histology and immunohistochemistry experience, and experience in microscopy and the use of bioreactors for tissue engineering and a workable knowledge of material characterization would be ideal. Candidates should have a PhD and preferably post-doctoral experience in cellular biology and cell-materials interactions, with knowledge of material characterization.
The group are looking to recruit ASAP and the appointment will be made, dependent on relevant qualifications and experience, within the Grade 6 scale, currently £30,749-,37,839 per annum, inclusive of £2,323 London Allowance, per annum. Benefits include an annual season ticket loan scheme and a final salary superannuation scheme.
For further information, please contact Dr Lucy Di Silvio on +44 207 188 1819 or by email on lucy.di_silvio@kcl.ac.uk; alternatively please contact Dr Jie Huang on +44 207 679 7183 or by email on jie.huang@ucl.ac.uk.
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